CitruSays® - Citrus Extract std. to Nobiletin

CitruSays™ is the brand name for premium Nobiletin Ingredient developed by Bonerge following compendial guidelines.

Nobiletin: Targeting the Circadian Network to Promote Bioenergetics and Healthy Aging


★ Supporting Healthy Aging: Nobiletin has potential application in extension of lifespan, and its associated healthspan and stress resistances.

★ Bolstering Your Bone Health: Research has shown that this powerful flavonoid suppresses the reduction of bone mineral density, it is a powerful weapon in the fight for stronger, younger bones.

★ Many Benefits From One Source: Other studies found the flavonoid have positive effects on prevents obesity, lowers blood cholesterol, and offers dynamic anti-stress and anti-aging nerve support. 

The basic information

Brand Name CitruSays ® 
Specification Nobiletin 10%-98%, or PMFs(Nobiletin+Tangeratin) 30%-90%
Botanical Source Citrus Aurantium. Immature fruit
Sterilization Dry heat. Non-irradiated
Kosher Kosher certified 
Halal Halal certified 
BSE/TSE Not of animal origin, BSE TSE free.
Allergen Known allergen free
Gluten Gluten free
Shelf Life 2 years when stored in proper condition
Storage Store in a cool dry place,away from direct sunlight

The Quality Control

Quality standards, including physical, chemical, and microbiological tests and criteria are important parts of the safety and efficacy of ingredients. Bonerge is aiming to offer premium-quality Nobiletin ingredients with potent healthy values to the world.


1. BongeLov Management System

All of our products are developed and operated under our BongeLov Management System. We are proud to hold and maintain a full set of the world-class manufacturing certifications including cGMP, GMP+, FSSC22000, HACCP, ISO22000, Halal, Kosher etc, our process allows Bonerge to continue to meet the highest standards for purity, traceability and transparency that’s backed by strict controls, monitoring and tracking to provide our customers with products they trust.


2.  Analytical Procedure Life Cycle Management

With professional analytical scientists and advanced equipments, top quality and consistency among batches are the golden promises to our customers from Bonerge.

The identity test, purity test, impurity test and assay test that usually applied in the pharmaceutical industry and guided by USP requirements, is at the center of Bonerge's quality research.


3. Authoritative and credible Reference Standard(RS) for assay analysis 

A trusted RS is like an impartial judge. Reference substances are of great importance for a test method.  Bonerge always source every RS globally, and choose the authoritative and credible Reference Standard for assay analysis .


4.  Top quality botanical source for eco-friendly and cost-efficiently manufacturing

 We are making efforts to manufacture eco-friendly and cost-efficiently to make our healthy ingredients more affordable to consumers. We work with the raw material growers closely to source high quality material that can be traced through every step.  Our facility equipped with two continuous countercurrent extraction lines, and each line is available in capacities of up to hundreds tons/day raw material, enable us to produce at super largre scale and achive the best quality and cost.

The Benefits Research

1. Nobiletin: Targeting the Circadian Network to Promote Bioenergetics and Healthy Aging

In recent years, an emerging topic of broad interest is clock-modulatory agents for healthy aging. Nobiletin is a naturally occurring flavonoid with the greatest abundance found in citrus peels. Extensive research has shown that Nobiletin is endowed with a wide range of biological activities, recently study found through unbiased chemical screening that Nobiletin impinges on the clock machinery to activate temporal control of downstream processes within the cell and throughout the body.
Using animal models of  aging, research illustrate potent beneficial effects of Nobiletin on cellular energetics in both periphery and brain to promote healthy aging. 
2. Nobiletin: A Polyphenol Boosts Many of Our Body Systems, especially bolstering bone health

Study found that nobiletin is useful in combating arthritis, the scientists also identified a bone health benefit. The researchers at Kyoto University tested the impact of five different compounds on female mice who had their ovaries removed. Of them, nobiletin, stood out as particularly potent, it significantly suppressed the reduction of whole bone mineral density by 61%.

Another study looking specifically at obesity and osteoporosis found that nobiletin prevented the reduction of bone mineral density in the femurs of mice.

3. The Secret Strength Of Citrus, Many Benefits From One Source

Nobiletin is found in abundance in many types of citrus fruit. Different types of citrus are rich in different flavonoids,Tangerines are a notable example. These natural compounds work against oxidation in the body and get us a holistic health solutions.

A study published in the journal Pharmacology and Pharmacy looked at the impact of nobiletin on mice that had an induced estrogen deficiency. They found that the mice who were given nobiletin had less weight gain, and improved adiposity, dyslipidemia and hyperglycemia.