GlucoVest® Dihydroberberine

GlucoVest® is the brand name for top quality  Dihydroberberine developed by Bonerge.

 

★ Dihydroberberine is A new form of berberine, more powerful and bioavailable than berberine (5 times better) for blood sugar and insulin control;

★ Dihydroberberine is the hottest natural herbal glucagon-like peptide 1 (GLP-1) agonist;

★ With large amounts of scientific research showing significant improvements of GLP-1 to insulin sensitivity, fasting glucose levels, HbA1c reduction, nutrient partitioning, and far more.

★ Improves cardiovascular health, weight loss, and cellular longevity by modulating various pathways and receptors.

 

The basic information

Brand Name GlucoVest
Product Name Dihydroberberine
Specification

Powder: Assay 97% with density suitable for tablet

Granular: Assay 97% with high density suitble for capsule

Sterilization Dry heat. Non-irradiated.
GMO Non-GMO.
BSE/TSE Not of animal origin.BSE TSE free. 
Allergen Known allergen free. 
Gluten Gluten free. 
Storage Store in a cool dry place,away from direct sunlight

The Quality Control

Quality standards, including physical, chemical, and microbiological tests and criteria are important parts of the safety and efficacy of ingredients. Bonerge is aiming to offer premium-quality Dihydroberberine ingredients with potent healthy values to the world.

 

1. BongeLov Management System

All of our products are developed and operated under our BongeLov Management System. We are proud to hold and maintain a full set of the world-class manufacturing certifications including cGMP, GMP+, FSSC22000, HACCP, ISO22000, Halal, Kosher etc, our process allows Bonerge to continue to meet the highest standards for purity, traceability and transparency that’s backed by strict controls, monitoring and tracking to provide our customers with products they trust.

 

2.  Analytical Procedure Life Cycle Management

With professional analytical scientists and advanced equipments, top quality and consistency among batches are the golden promises to our customers from Bonerge.

The identity test, purity test, impurity test and assay test that usually applied in the pharmaceutical industry and guided by USP requirements, is at the center of Bonerge's quality research.

 

3. Authoritative and credible Reference Standard(RS) for assay analysis 

A trusted RS is like an impartial judge. Reference substances are of great importance for a test method.  Bonerge always source every RS globally, and choose the authoritative and credible Reference Standard for assay analysis .

 

4.  Top quality botanical source for eco-friendly and cost-efficiently manufacturing

 We are making efforts to manufacture eco-friendly and cost-efficiently to make our healthy ingredients more affordable to consumers. We work with the raw material growers closely to source high quality material that can be traced through every step.  Our facility equipped with two continuous countercurrent extraction lines, and each line is available in capacities of up to hundreds tons/day raw material, enable us to produce at super largre scale and achive the best quality and cost.

The Benefits Research

Dihydroberberine Helps To Improve Glucose and Lipid Metabolic Health

Until now, there are large amounts of scientific research showing that in reduce blood sugar levels; promote lipid conversion; help for loss weight, Dihydroberberine(DHB) has better effect than Berberine(BBR).

 

1. Maintain Blood Sugar Standard

BBR has been showen to adjust Sugar metabolism in human body through reduced glucose absorption; inhibit gluconeogenesis; regulate insulin levels; active PKC and AMPK.

DHB shows better effect than BBR in adjust sugar metabolism, a study, which the subjects were mice shows BBR and DHB all can improve 44% insulin sensitivity. Compared with DHB and BBR for improving insulin sensitivity. The results shows that to cause the same reaction with DHB, you need five times more than BBR.

 

2. Lipid Metabolism

The effect of BBR on fat loss is thought to be related to the improvement of insulin sensitivity and the activation of AMPK enzyme. In addition, BBR has been shown to lower cholesterol levels and thus reduce the risk of heart disease, this is thought to be caused by BBR's inhibitory effect on an enzyme called PCSK9, which when inhibited causes more LDL (bad cholesterol) to be removed from the blood.

One study compared the pancreatic lipase inhibition of BBR and DHB, the results shows that because of the affinity of DHB is stronger than BBR, the BBR has a lower inhibitory action compared to DHB on pancreatic lipase.

 

3. Weight Loss and Prevent Obesity

BBR can regulate blood glucose and lipid balance in many ways, indicating that it can help regulate body weight. In one study, subjects were given BBR over time, after 12 weeks, their BMI levels dropped from 31.5 to 27.4. DHB has stronger ability in these aspect,so DHB may be considered a more effective weight-loss aid than BBR.

 

 

Reference

1. Wang Y, Campbell T, Perry B, Beaurepaire C, Qin L (2011) Hypoglycemic and insulin-sensitizing effects of berberine in high-fat diet- and streptozotocin-induced diabetic rats. Metabolism 60: 298-305.

2. Turner N, Li JY, Gosby A, et al. Berberine and its more biologically available derivative, dihydroberberine, inhibit mitochondrial respiratory complex I: a mechanism for the action of berberine to activate AMP-activated protein kinase and improve insulin action. Diabetes. 2006 Mar;55(3):708-15. doi: 10.2337/diabetes.55.03.06.db05-0312.

3. Paavola, K.J. and R.A. Hall, (Polygala Tenuifolia)receptors: signaling, pharmacology, and mechanisms of activation. Molecular pharmacology, 2018. 82(5): p. 777-783.