UroAce®, The Ace of Urolithin

 

UroAce® is the brand name for top quality Urolithin A and Urolithin A-diacetate developed by Bonerge following compendial guidelines.

★ Urolithin A is one of the most clinically studied supplements in longevity space;

★ Urolithin A offers a unique approach by targeting mitochondrial health and promoting cellular rejuvenation through its specific activation of autophagy of mitochondria;

★ Urolithin A help to boost hematopoietic stem cells (HSCs) function and improves the immune response.

★ Urolithin A help strengthen skeletal muscles in the elderly group, and significantly enhances muscle strength, exercise performance and activity levels across all age groups.

The basic information

Brand Name UroAce
Product Name Urolithin A, Urolithin A-diacetate
Specification Purity NLT 98% by HPLC
Description Urolithin A: Pale yellow to yellow powder
  Urolithin A-diacetate: Off white to white powder
Sterilization Method Dry heat. Non-irradiated.
GMO Non-GMO.
BSE/TSE Not of animal origin.BSE TSE free. 
Allergen Known allergen free. 
Gluten Gluten free. 
Storage Store in a cool dry place,away from direct sunlight

The Quality Control

Quality standards, including physical, chemical, and microbiological tests and criteria are important parts of the safety and efficacy of ingredients. Bonerge is aiming to offer premium-quality Urolithin A ingredients with potent healthy values to the world.

 

1. UroAce stands out for its pure colour and lower impurities

 

 

2.  A full set of quality characterization make sure you get the ture and the best Urolithin A

With professional analytical scientists and advanced equipments, top quality and consistency among batches are the golden promises to our customers from Bonerge.

The identity test, purity test, impurity test and assay test that usually applied in the pharmaceutical industry and guided by USP requirements, is at the center of Bonerge's quality research.

 

 

3. BongeLov Management System

All of our products are developed and operated under our BongeLov Management System. We are proud to hold and maintain a full set of the world-class manufacturing certifications including cGMP, GMP+, FSSC22000, HACCP, ISO22000, Halal, Kosher etc, our process allows Bonerge to continue to meet the highest standards for purity, traceability and transparency that’s backed by strict controls, monitoring and tracking to provide our customers with products they trust.

 

4.  Analytical Procedure Life Cycle Management

With professional analytical scientists and advanced equipments, top quality and consistency among batches are the golden promises to our customers from Bonerge.

The identity test, purity test, impurity test and assay test that usually applied in the pharmaceutical industry and guided by USP requirements, is at the center of Bonerge's quality research.

 

The Benefits Research

Urolithin A , Boosting Mitochondrial Health by Triggering Mitophagy

 

One of the biggest benefits of Urolithin A(UA) is to boost the mintochondrial health by triggering mitophagy, and to improve the cell energy.

It is well known that mitochondria are cell stations, a tiny organelles that convert glucose and oxygen into adenosine triphosphate as energy.

(1) Mitochondrial function declines with age and its ability to provide energy to cells decreases.

(2) Mitochondrial dysfunction is one of the important hallmarks of aging that cause cell damage and lead to age-related issues. 

(3) Mitochondrial abnormalities lead to loss of muscle strength. 

 

Many studies have reported that UA improves mitochondrial health by promoting mitophagy to cope with age-related issues, and can also enhance muscle strength.

In a clinical trial, researchers found that long-term UA supplementation significantly improved skeletal-muscle specific endurance and also improved mitochondrial function in older adults, suggesting that UA inhibits age-related muscle decline.

 

 

 

Reference

1. Anurag S,  Davide D,  Pénélope A. A,  Andréane M. F, William B, Mal E, Patrick A, Johan A, Chris R. Urolithin A improves muscle strength, exercise performance, and biomarkers of mitochondrial health in a randomized trial in middle-aged adults. [J].Cell Reports Medicine. 

2. Dongryeol RLaurent Mouchiroud, etc Urolithin A induces mitophagy and prolongs lifespan in C. elegans and increases muscle function in rodents. [J]. Nature Medicine. 22, 879–888 (2016).

3. Dominic D, Valentina P, etc. Expansion of T memory stem cells with superior anti-tumor immunity by Urolithin A-induced mitophagy. [J]. Immunity.