Urolithin A 98%

★ Urolithin A is one of the most clinically studied supplements in longevity space;

★ Urolithin A improves cellular energy, muscle health and supports healthy aging;

★ Urolithin A offers a unique approach by targeting mitochondrial health and promoting cellular rejuvenation through its specific activation of autophagy of mitochondria;

The Brief Info

Product Name Urolithin A
Specification Purity NLT 98% by HPLC
Start Material Pomegranate Extract
Description Light yellow powder
Sterilization Method Dry heat. Non-irradiated.
GMO Non-GMO.
BSE/TSE Not of animal origin.BSE TSE free. 
Allergen Known allergen free. 
Gluten Gluten free. 
Storage Store in a cool dry place,away from direct sunlight

 

 

The Detail

Urolithin A , Boosting Mitochondrial Health by Triggering Mitophagy

 

One of the biggest benefits of Urolithin A(UA) is to boost the mintochondrial health by triggering mitophagy, and to improve the cell energy.

It is well known that mitochondria are cell stations, a tiny organelles that convert glucose and oxygen into adenosine triphosphate as energy.

(1) Mitochondrial function declines with age and its ability to provide energy to cells decreases.

(2) Mitochondrial dysfunction is one of the important hallmarks of aging that cause cell damage and lead to age-related issues. 

(3) Mitochondrial abnormalities lead to loss of muscle strength. 

 

Many studies have reported that UA improves mitochondrial health by promoting mitophagy to cope with age-related issues, and can also enhance muscle strength.

In a clinical trial, researchers found that long-term UA supplementation significantly improved skeletal-muscle specific endurance and also improved mitochondrial function in older adults, suggesting that UA inhibits age-related muscle decline.

 

 

 

Reference

1. Anurag S,  Davide D,  Pénélope A. A,  Andréane M. F, William B, Mal EPatrick AJohan AChris R. Urolithin A improves muscle strength, exercise performance, and biomarkers of mitochondrial health in a randomized trial in middle-aged adults. [J].Cell Reports Medicine. 

2. Dongryeol RLaurent Mouchiroud, etc Urolithin A induces mitophagy and prolongs lifespan in C. elegans and increases muscle function in rodents. [J]. Nature Medicine. 22, 879–888 (2016).

3. Dominic D, Valentina P, etc. Expansion of T memory stem cells with superior anti-tumor immunity by Urolithin A-induced mitophagy. [J]. Immunity.