Dihydroberberine 97% HPLC

★ Berberine is one of the best known and most effective natural Glucose Disposal Agents. 

★ With large amounts of scientific research showing significant improvements of Berberine to insulin sensitivity, fasting glucose levels, HbA1c reduction, nutrient partitioning, and far more.

★ Research suggests that dihydroberberine is up to 5 times better than standard berberine, bringing incredible effects at lower doses - and fewer side effects.

The Brief Info

Product Name Dihydroberberine (Powder & Granular)

Powder: Purity NLT 97% by HPLC

Granular: Purity NLT 95% by HPLC

Botanical source Berberis Aristata, Family Berberidaceaetract
Sterilization Dry heat. Non-irradiated.
BSE/TSE Not of animal origin.BSE TSE free. 
Allergen Known allergen free. 
Gluten Gluten free. 
Storage Store in a cool dry place,away from direct sunlight

The Detail

Dihydroberberine Helps To Improve Glucose and Lipid Metabolic Health

Until now, there are large amounts of scientific research showing that in reduce blood sugar levels; promote lipid conversion; help for loss weight, Dihydroberberine(DHB) has better effect than Berberine(BBR).


1. Maintain Blood Sugar Standard

BBR has been showen to adjust Sugar metabolism in human body through reduced glucose absorption; inhibit gluconeogenesis; regulate insulin levels; active PKC and AMPK.

DHB shows better effect than BBR in adjust sugar metabolism, a study, which the subjects were mice shows BBR and DHB all can improve 44% insulin sensitivity. Compared with DHB and BBR for improving insulin sensitivity. The results shows that to cause the same reaction with DHB, you need five times more than BBR.


2. Lipid Metabolism

The effect of BBR on fat loss is thought to be related to the improvement of insulin sensitivity and the activation of AMPK enzyme. In addition, BBR has been shown to lower cholesterol levels and thus reduce the risk of heart disease, this is thought to be caused by BBR's inhibitory effect on an enzyme called PCSK9, which when inhibited causes more LDL (bad cholesterol) to be removed from the blood.

One study compared the pancreatic lipase inhibition of BBR and DHB, the results shows that because of the affinity of DHB is stronger than BBR, the BBR has a lower inhibitory action compared to DHB on pancreatic lipase.


3. Weight Loss and Prevent Obesity

BBR can regulate blood glucose and lipid balance in many ways, indicating that it can help regulate body weight. In one study, subjects were given BBR over time, after 12 weeks, their BMI levels dropped from 31.5 to 27.4. DHB has stronger ability in these aspect,so DHB may be considered a more effective weight-loss aid than BBR.




1. Wang Y, Campbell T, Perry B, Beaurepaire C, Qin L (2011) Hypoglycemic and insulin-sensitizing effects of berberine in high-fat diet- and streptozotocin-induced diabetic rats. Metabolism 60: 298-305.

2. Turner N, Li JY, Gosby A, et al. Berberine and its more biologically available derivative, dihydroberberine, inhibit mitochondrial respiratory complex I: a mechanism for the action of berberine to activate AMP-activated protein kinase and improve insulin action. Diabetes. 2006 Mar;55(3):708-15. doi: 10.2337/diabetes.55.03.06.db05-0312.

3. Paavola, K.J. and R.A. Hall, (Polygala Tenuifolia)receptors: signaling, pharmacology, and mechanisms of activation. Molecular pharmacology, 2018. 82(5): p. 777-783.